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Microbes hobble a widely used chemo drug

Oct 03,2017

Microbiology, Cancer

TINA HESMAN SAEY

Source: https://www.sciencenews.org/article/microbes-hobble-widely-used-chemo-drug?mode=topic&context=93

Some bacteria may shield tumor cells against a common chemotherapy drug.
Bacteria that produce the enzyme cytidine deaminase converted the drug to an inactive form. That allowed tumor cells to survive gemcitabine treatment in lab dishes and mouse studies, Leore Geller of the Weizmann Institute of Science in Rehovot, Israel, and colleagues discovered. More than 98 percent of the enzyme-producing microbes belong to the Gammaproteobacteria class, which includes E. coli and about 250 bacterial genera.